Enzymes are chemical substances produced in the living organism.
They are marvellous organic catalysts which are essential to life
as they control all the chemical reactions that take place in a
living system. Enzymes are part of all living cells, including those
of plants and animals.
The term enzyme, which literally means in yeast', was coined following
the demonstration of catalytic properties of yeast and yeast juices.
Although enzymes are produced in the living cell, they are not dependent
upon the vital processes of the cell and work outside the cell.
Certain enzymes of yeast, for instance, when expressed from the
yeast cells are capable of exerting their usual effect, that is,
the conversion of sugar to alcohol.
A striking feature of enzymes is that while they enter into chemical
reaction, they remain intact in the process. They however, act with
maximum efficiency at a certain temperature. Lowering the temperature
below or raising it above this level slows the reaction. A high
degree of heat, that is above 60 o C, permanently destroys their
action.
It has been estimated that there are over 20,000 enzymes in the
human body. This estimate is based on the number of bodily processes
that seem to require action. However, so far only about 1,000 enzymes
have been identified. But their great role in nutrition and other
living processes has been firmly established. They are protein molecules
made up of chains of amino acids. They play a vital role and work
more efficiently than any reagent concocted by chemists. Thus for
instance, a chemist can separate proteins into their component amino
acids by boiling them at 166 o C for over 18 hours in a strong solution
of hydrochloric acid, but the enzymes of the small intestines can
do so in less than three hours at body temperature in a neutral
medium.
A feature which distinguishes enzymes from inorganic catalysts
is that they are absolutely specific in their actions. This means
that a particular enzyme can cause reactions involving only a particular
type of substance or a group of closely related substances. The
substance on which the enzyme acts is known as "substrate".
The specificity of an enzyme is, however, related to the formation
of the enzyme-substrate complex which requires that the appropriate
groupings of both substrate and enzyme should be in correct relative
position. The substrate must fit the enzyme like a key fits its
lock.
Enzymes which are used in the cells which make them are called
intracellular enzymes. Enzymes which are produced in cells which
secrete them to other parts of the body are known as extracellular
enzymes. Digestive juices are an example of the latter type.
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